Tolera Therapeutics - Bringing Targeted and Safer Therapies to Market

PRESS RELEASE

Tolera Therapeutics announces new board members

Monday, June 16, 2008- Tolera Therapeutics Inc., a newly formed biotechnology company focusing on the development of immunotherapeutics directed at the transplantation, oncology and autoimmune disease markets, announced today that it has added two new board members following the closing its Series A financing. The company's board will add two new members, Suzette Dutch of Triathlon Medical Ventures and Douglas R. Morton, Jr. PhD of the Southwest Michigan First Life Sciences Fund.

"This is an exciting time for the company," commented CEO John Puisis, "and as a young company we are fortunate to tap into the depth of pharmaceutical and clinical development experience that Suzette and Doug bring to the table as we approach the FDA, and clinicians, with our next generation therapeutics".

Suzette Dutch of Triathlon Medical Ventures added: "We are delighted to lead this first institutional funding round for Tolera, a company with a promising technology platform and a near term product with human data evidencing key advantages in transplantation. We look forward to working with our fellow investors to support the management team in realizing the value of the company's most promising opportunities".

"The Southwest Michigan First Life Science Fund is very pleased to participate in the Series A financing of Tolera Therapeutics," commented Doug Morton, "and we are excited to work with the Tolera leadership team on the translation of its lead candidate and technology platform to meet important medical needs."

Dutch and Morton join current board members Donald R. Parfet, Managing Director of Apjohn Group, LLC, who joined the board last year, CEO Puisis, and Sam Kiderman of Cleveland Clinic Innovations.

About Suzette Dutch and Triathlon Medical Ventures: Suzette Dutch, Managing Partner of Triathlon Medical Ventures, has 20 years venture investing and 10 years operating experience in pharmaceuticals, surgical devices and diagnostics. At Senmed she served on the investment committee and led the strategic planning, clinical/regulatory, market and business development due diligence efforts for start-ups through later stage investments. She has held various positions in clinical studies design, market research, and corporate planning at SmithKline, integrating the acquisitions of Allergan, Beckman, and Clinical Laboratories. She has an MBA from Wharton in Finance and Decision Science, and a BA in economics from Case Western Reserve University. She is currently on the Board of Directors of Biovex and an observer on Akebia, and was on the Board of Directors of Renal Solutions prior to its acquisition by Fresenius. Triathlon Medical Ventures is a Midwest-based venture capital firm that invests exclusively in the life sciences. To learn more about Triathlon Medical Ventures, go to www.tmvp.com.

About Doug Morton and Southwest Michigan First: Doug is a consultant to the pharmaceutical industry, specializing in discovery, early development and strategic alliances. He was previously CEO, Ssouthwest Michigan Innovation Center located in Kalamazoo, Michigan. He spent the majority of his career in the pharmaceutical industry, joining the Upjohn Company as a research scientist in 1973. He remained with the surviving entity through Upjohn's merger with Pharmacia AB (in 1996), the consolidation of Pharmacia & Upjohn with Monsanto (in 2000), and Pharmacia's merger with Pfizer (2003), serving in a series of increasingly significant discovery research management positions. At the time of the Pfizer merger, he was Group Vice President, Technology Acquisitions & Operations for Discovery Research in Pharmacia Corporation.. Doug holds an A.B. in from Kenyon College and a Ph.D. in Organic Chemistry from Columbia University. He subsequently completed postdoctoral studies in organic chemistry at Stanford University. Doug has served and continues to serve on the Boards of Directors and Scientific Advisory Boards (SAB) of several life science start up companies. He also serves on the SAB and Management Committee of the Southwest Michigan Life Science Fund, the SAB of Hopen Therapeutics and also serves on the Industrial Advisory Board of the Cleveland Clinic Foundation Innovations. The Southwest Michigan First Life Science Fund is a limited partnership venture fund interested in early stage life science opportunities that have demonstrably viable technologies. More information about the Southwest Michigan First Life Science Fund can be found at www.southwestmichiganfirst.com/wmlifesciencecompanies.cfm.

About Tolera Therapeutics: Building upon research done at the University of Kentucky and the Cleveland Clinic, Tolera Therapeutics is developing and commercializing therapies for the immune suppression / modulation market with the goal of addressing unmet medical needs with safer, more targeted solutions to reduce the risk of serious and toxic side effects. The company is focusing first on commercializing a therapeutic monoclonal antibody for the transplantation and oncology markets, while researching and developing related therapies for those suffering from autoimmune diseases such as diabetes (Type 1). The company owns an exclusive, worldwide license to its antibody technology, including chimeric and humanized clones, which has already undergone extensive research, development and human studies. Additional information concerning the company and its technology can be found on its website www.tolera.com.

Company contact: 
John Puisis
Chief Executive Officer
800-695-1554
jpuisis@tolera.com